Supports healthy liver function and detoxification*
• Milk thistle seed extract and curcumin promote antioxidant support by increasing levels of the endogenous antioxidant glutathione (GSH) and decreasing lipid peroxidation*
• Provides standardized extracts from milk thistle seed, turmeric rhizome and licorice root
• Includes lipotropes choline and L-methionine

GENESTRA BRANDS Liver Support and Detoxification* provides a combination of nutrients and herbs that promote a healthy liver, the primary site for the detoxification of metabolic waste products.^1-6* Research demonstrates that milk thistle increases the activity of detoxifying enzymes in the liver.¹* Along with active ingredients in turmeric and licorice, milk thistle supports and enhances the body’s antioxidant defense system.^2-4* Milk thistle and licorice also promote a healthy cytokine balance to further maintain liver health.^2,4* In a randomized, placebo-controlled trial, daily supplementation with 140 mg of silymarin (the primary bioactive in milk thistle) for two months significantly promoted healthy levels of the liver enzymes alanine transaminase (ALT) and aspartate transaminase (AST), two important clinical markers of healthy liver function.^6,7* Lipotropic compounds, including choline and L-methionine, are also included to support healthy lipid metabolism in the liver.⁵*

REFERENCES
1. Zhao, J, Agarwal, R. 1999: 20(11): 2101-2108.
2. Trappoliere, M, Caligiuri, A, Schmid, M, Bertolani, C, Failli, P, Vizzutti, F, Novo, E, di Manzano, C, Marra, F, Loguercio, C, Pinzani, M. Journal of Hepatology. 2009; 50: 1102–1111.
3. Reyes-Gordillo, K, Segovia, J, Shibayama, M, Vergara, P, Moreno, MG, Muriel, P. Biochimica et Biophysica Acta. 2007; 1770: 989–996.
4. Lee, CH, Park, SW, Kim, YS, Kang, SS, Kim, JA, Lee, SH, Lee, SM. Biol. Pharm. Bull. 2007; 30(10): 1898—1904.
5. Fardet, A, Martin, JF, Chardigny, JM. Journal of Food Composition and Analysis. 2011; 24: 895–915.
6. Giannini, EG, Testa, R, Savarino, V. CMAJ. 2005; 172(3): 367-79.
7. Hajaghamohammadi, AA, Ziaee, A, Rafiei, R. 2008; 8(3): 191-195.