Angiogenesis involves a complex cascade of events that results in the growth of new blood vessels from existing microvascular structures.  The process of angiogenesis is absolutely necessary for growth and development. This means that any inhibitors of angiogenesis should be avoided in childhood, pregnancy or circumstances where patent blood vessels or neovascularization is obligatory.   Inhibition of new blood vessel growth may cause fetal malformations. New blood vessel growth (angiogenesis) is a normal body function e.g. wound repair.
Blood vessel structures are controlled by a balancing act that involves growth factors, which promote angiogenesis and factors that inhibit angiogenesis.  Therefore, it is somewhat naïve to think about simple angiogenic promotion or inhibition, because these processes are subject to modulation by a variety of different biological response modifiers. One may understand the limitations of the use of “single agents” that may inhibit angiogenesis, such as shark cartilage or its extracts.*

The role of the modification of angiogenesis has been pioneered by Moses Judah Folkam MD.  While angiogenesis plays a pivotal role in normal events such as wound healing, menstruation and fetal development, there are many disorders that result from disturbed angiogenesis.  These angiogenic-dependent circumstances include diabetic retinopathy, psoriasis, arthritis and cancer.  The role of angiogenesis in the promotion of tumor growth, cancer progression, proliferation and metastatic spread of cancer have been widely researched. These are drug treatment approaches to antiangiogenesis and such claims cannot be made for dietary supplements.*

There are many different types of natural angiogenesis inhibitors with varying toxicity.  The complexities of the process of angiogenesis results predictably in the existence of many different substances with different targets of action on the complex cascade of events. While many natural substances, that can be used in dietary supplements, are known to exert varying degrees of antiangiogenic effects, it is not possible to make claims about natural angiogenesis modulation in disease treatment (variable evidence).*

Not enough attention has been focused on modulators of the body function of angiogenesis from natural sources.  Several such compounds have been discovered. Natural modulators of angiogenesis include: Bovine Cartilage, Chitin, N-Acetyl-Glucosamine, Chicken Cartilage, Sea Cucumber, Quercetin Dihydrate, Garlic, Green Tea 95% Polyphenols, Papain, Aloe Vera 200:1 Extract, Ellagic Acid (From Pomegranate), Grape Seed Extract (95% OPC), Soy Isoflavones, Magnolia Bark Extract (1.5% Honokiol), Pine Bark Extract (85% Proanthocyanidins), Vitamin A and Vitamin D3.*

Supplement Facts
Servings per container: 30
Serving size: 6 capsules contain

• Bovine Cartilage   1000 mg
• Chitin   500 mg
• N-Acetyl-Glucosamine   500 mg
• Chicken Cartilage   250mg
• Sea Cucumber   200 mg
• Quercetin Dihydrate   200 mg
• Garlic   100 mg
• Green Tea (95% polyphenols)   100 mg
• Papain   100 mg
• Aloe Vera (200:1 extract)   50 mg
• Ellagic Acid (from pomegranate)   50 mg
• Grape Seed Extract (95% OPC)   50 mg
• Soy isoflavones   30 mg
• Magnolia Bark Extract (1.5% Honokiol)   20 mg
• Pine Bark Extract (85% Proanthocyanidins)   10 mg
• Vitamin A   10000 IU
• Vitamin D3   800 IU

Other ingredients: gelatin, cellulose, and magnesium.