This synergistic proteolytic enzyme formula provides systemic support for muscle, joint and overall tissue health. Enzymes included in this formula have the potential to influence bradykinin formation, modulate the arachidonic cascade and prostaglandin E2 production, and provide fibrinolytic support. All of these actions contribute to the potential of proteolytic enzymes to maintain healthy immune mediator activity at the cellular level and overall tissue health. In addition, proteolytic enzymes have been found to support muscle comfort and recovery of contractile function, as indicated in one placebo controlled human study involving athletes. Animal studies have indicated that some proteolytic enzymes may result in enhanced muscle recovery. Furthermore, proteolytic enzymes support joint and cartilage comfort. Rutin, a flavonol, was shown in several animal studies to promote joint health better than other flavonols and is included in this formula to complement both its musculoskeletal and tissue support potential. Boswellia serrata is an Ayurvedic herb that has a long history of use for connective tissue and joint support. Boswellic acids, the terpenoid constituents of boswellia, maintain healthy 5-lipoxygenase enzyme activity and healthy leukotriene metabolism. In addition, boswellic acids may maintain healthy human leukocyte elastase enzyme activity, preserving the integrity of healthy connective tissue. For systemic support, this formulation should be taken between meals. Serrazimes, a serrapeptidase-comparable enzyme blend, helps lessen minor pain and maintains a healthy inflammatory response.*